Bacterial Virulence in the Moonlight: Multitasking Bacterial Moonlighting Proteins Are Virulence Determinants in Infectious Disease
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چکیده
منابع مشابه
Multitasking Bacterial Moonlighting Proteins in Bacterial Virulence and Infectious Disease
Men may not be able to multitask, but it seems that proteins can. Although the one gene-one protein-one function hypothesis is well ingrained in the Central Dogma, it has become clear during the past decade that many proteins have one or more unique functions in addition to their primary biological action. These proteins perform multiple independent and often unrelated roles without partitionin...
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Implicit in the central dogma is the hypothesis that each protein gene product has but one function. However, over the past decade, it has become clear that many proteins have one or more unique functions, over-and-above the principal biological action of the specific protein. This phenomenon is now known as protein moonlighting and many well-known proteins such as metabolic enzymes and molecul...
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M any mammalian and plant pathogenic bacteria inject virulence effector proteins into host cells by means of the type III secretion system (TTSS) (1). Effector proteins attack the host innate immune system, modify cytoskeleton and membranes, or alter vesicle trafficking (2, 3). The collective action of these proteins promotes bacterial entry into, growth and movement within, and dissemination f...
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Bacterial stress responses provide them the opportunity to survive hostile environments, proliferate and potentially cause diseases in humans and animals. The way in which pathogenic bacteria interact with host immune cells triggers a complicated series of events that include rapid genetic re-programming in response to the various host conditions encountered. Viewed in this light, the bacterial...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2011
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00179-11